059 IL-31 causes anxiety-like behavior in a mouse model of atopic dermatitis

Atopic dermatitis (AD) is a chronic, recurrent, itchy, inflammatory skin disease. The coexistence of anxiety, depression, and social withdrawal problematic in AD. Although an association between AD anxiety depressive behavior has been observed humans few mouse models, the detailed mechanisms are unknown. To address this issue, we analyzed mental state mice using models. We sensitized with 3% oxazolone (OXA) then repeatedly applied 0.6% OXA to ears 3 times per week for 4 weeks. In these mice, auricule changed AD-like appearance, scratching was observed. Followingly, conducted behavioral tests evaluate depression anxiety. evaluated by open field test light/dark transition test, forced swim tail suspension test. showed anxiety-like whereas control did not. No significant difference found other three tests. hypothesized that itching atopic cause behaviors mice. question, focused on IL-31, cytokine strongly associated IL-31 administered continuously at dose 2μg day weeks osmotic pump behavior. IL-31-treated severe alopecia. tendencies no differences were tendencies, which consistent results OXA-induced model. These findings suggest induced model, possibly via IL-31-induced pruritus.